Formulation Development

At Cubi-Tech, we have multiple formulation platforms to take materials from the discovery phase all the way to proof of concept phase, efficiently and economically, to provide our clients with the clearest path to commercial success.

Through our analytical and formulation technologies, operated by our development experts, Cubi-Tech can tailor a consolidated drug formulation program customised precisely according to your requirements. Our goal is to accelerate your product to the next stage of drug development as efficiently as possible.

Please click on one of the below sections to find out how Cubi-Tech can impact your project at the formulation stage:

Particle size reduction

Cubi-tech is able to offer a number of particle size reducing solutions for our clients products, during all stages of API development and manufacture. Reduction to a carefully designed, specific particle size parameters can help improve flow properties, provide uniform particle characteristics and can improve drug solubility. These factors can have far reaching consequences, on the performance of a drug product, whether during the manufacture stage way to a drugs bio availability.

Achieving a uniform powder with adequate flow properties is essential to achieving continuous and consistent manufacture.
At Cubi-Tech we can achieve a wide range of particle sizes utilising a variety of different methods.

From simple deagglomeration to micronisation, Cubi-tech has a range of capabilities including:

  • Conical milling for uniform particle size reduction
  • Ball Milling
  • Cutter Milling
  • Jet Milling

Tableting

Cubi-tech offers a well equipped in-house, GMP tableting laboratory, to provide reliable and fast small scale, GMP tablet manufacturing. Utilizing our Kambert table top rotary press, we are able to design and produce tablets for R&D, formulation and product development purposes.

Our tablet press can use either direct compression techniques or through combination with our twin screw extruder or conical milling capabilities can work with materials that require pre-granulation.

Cubi-Tech has the capabilities to process up to 15,000 tablets per hour in batch sizes of up to 50kg.

We are equipped to handle up to OEL class 4 materials

Our lab is outfitted with relevant tablet characterization equipment to validate your tablets physical properties such as; Dissolution, Disintegration, Friability, Hardness and weight variation.

Amorphous Solid Dispersion Development

Cubi-Tech is able to efficiently identify the ideal candidates to process with your API, and tailor solid dispersions of your APIs to meet your dissolution needs

Cubi-Tech employees a state of the art Pharma 11 Twin-screw Extruder, to develop a continuous, cost-effective, easily scalable, rapid and environmentally friendly method to produce solid dispersions of your API, in our state-of-the-art GMP extrusion lab.

With a range of down streaming equipment and extruder Dies available we are able to produce your solid dispersions in a range of different forms. Using our extruder dies we can produce them as Films or filaments, and utilizing down-streaming options such as Pelletization, spheronization or our Kambert Mini Rotary Press, we are able to make pellets, spheres and different tablet forms. We have complete size control over all these methods so can tailor the dosage form to your demand.

Cubi-Tech staff has years of experience and expertise in extrusion technology, so you can rest assured your Solid dispersions process will be carried out to the highest possible calibre.

Multi-component system development

Multi-component systems encompass a wide range of dosage forms such as Cocrystals, Hydrates, Salts and solvates and offer unique ways to enhance an API. These systems allow an expedient way to alter a number of physicochemical properties of APIs including dissolution rate, intrinsic solubility, melting point, hygroscopicity, compressibility, bulk density, and friability.

Cubi-Tech offers Rapid, efficient, scalable, continuous and cost effective production means to process your tailormade formulation, using our state-of-the-art extrusion line.

With a range of down-streaming options such as Pelletization, spheronization or our GMP grade Automatic Tablet Press, we are able to make pellets, spheres and different tablet forms to suit our clients needs. Our staff are experienced in the area of multi-component delivery and will work with clients to formulate and develop a the most suitable system for your API.

Particle size reduction

Particle size reduction

Cubi-tech is able to offer a number of particle size reducing solutions for our clients products, during all stages of API development and manufacture. Reduction to a carefully designed, specific particle size parameters can help improve flow properties, provide uniform particle characteristics and can improve drug solubility. These factors can have far reaching consequences, on the performance of a drug product, whether during the manufacture stage way to a drugs bio availability.

Achieving a uniform powder with adequate flow properties is essential to achieving continuous and consistent manufacture.
At Cubi-Tech we can achieve a wide range of particle sizes utilising a variety of different methods.

From simple deagglomeration to micronisation, Cubi-tech has a range of capabilities including:

  • Conical milling for uniform particle size reduction
  • Ball Milling
  • Cutter Milling
  • Jet Milling
Tableting

Tableting

Cubi-tech offers a well equipped in-house, GMP tableting laboratory, to provide reliable and fast small scale, GMP tablet manufacturing. Utilizing our Kambert table top rotary press, we are able to design and produce tablets for R&D, formulation and product development purposes.

Our tablet press can use either direct compression techniques or through combination with our twin screw extruder or conical milling capabilities can work with materials that require pre-granulation.

Cubi-Tech has the capabilities to process up to 15,000 tablets per hour in batch sizes of up to 50kg.

We are equipped to handle up to OEL class 4 materials

Our lab is outfitted with relevant tablet characterization equipment to validate your tablets physical properties such as; Dissolution, Disintegration, Friability, Hardness and weight variation.

Amorphous Solid Dispersion Development

Amorphous Solid Dispersion Development

Cubi-Tech is able to efficiently identify the ideal candidates to process with your API, and tailor solid dispersions of your APIs to meet your dissolution needs

Cubi-Tech employees a state of the art Pharma 11 Twin-screw Extruder, to develop a continuous, cost-effective, easily scalable, rapid and environmentally friendly method to produce solid dispersions of your API, in our state-of-the-art GMP extrusion lab.

With a range of down streaming equipment and extruder Dies available we are able to produce your solid dispersions in a range of different forms. Using our extruder dies we can produce them as Films or filaments, and utilizing down-streaming options such as Pelletization, spheronization or our Kambert Mini Rotary Press, we are able to make pellets, spheres and different tablet forms. We have complete size control over all these methods so can tailor the dosage form to your demand.

Cubi-Tech staff has years of experience and expertise in extrusion technology, so you can rest assured your Solid dispersions process will be carried out to the highest possible calibre.

Multi-component system development

Multi-component system development

Multi-component systems encompass a wide range of dosage forms such as Cocrystals, Hydrates, Salts and solvates and offer unique ways to enhance an API. These systems allow an expedient way to alter a number of physicochemical properties of APIs including dissolution rate, intrinsic solubility, melting point, hygroscopicity, compressibility, bulk density, and friability.

Cubi-Tech offers Rapid, efficient, scalable, continuous and cost effective production means to process your tailormade formulation, using our state-of-the-art extrusion line.

With a range of down-streaming options such as Pelletization, spheronization or our GMP grade Automatic Tablet Press, we are able to make pellets, spheres and different tablet forms to suit our clients needs. Our staff are experienced in the area of multi-component delivery and will work with clients to formulate and develop a the most suitable system for your API.

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